Effect of Sleeve Gastrectomy With Pancreatic Omentoplasty On Pancreatic Vegf Intensity In Non-Obesity Diabetes Mellitus Rats

Diabetes mellitus is one of the most common non-communicable diseases that still growing today especially diabetes type 2 (DMT2). in non-obese patients an important problem to solve because it tends be worse than DM obese patients. Chronic hyperglycemia can damage body tissues through several mechanisms like polyol pathway, hexosamine activation protein kinase C (PKC) and advance glycation end products (AGEs). This pathway pancreas so insulin cannot secreted worsen condition diabetes. Sleeve gastrectomy procedure secrete hormones such as insulin, GLP-1, PYY (Peptide YY) dan PP (Pancreatic polypeptide) which play a role regulation glucose blood. Omentoplasty cell regeneration, Langerhans β cells produced adequately. Objective evaluate effect Gastrectomy Pancreas on Pancreatic VEGF Intensity rats. Methods True experimental study with "post-test only control design" 18 rats Mellitus was divided into 3 groups: K (control), P1 (Sleeve Gastrectomy), P2 + Omentoplasty). 10 days after procedure, we evaluated using immunohistochemistry. Statistical analysis One Way ANOVA Post Hoc LSD. Result increased P2. In all groups pancreatic levels were statistically significant (p = <0.01). Conclusion mellitus.